When a virtual memory page has to be attached to the VAS, if a page fault occurs, it’s handled by the OS. So 64K will give you less page faults than 4K simply because of the size of the page.
For the same reason as huge pages, TLB also benifits.
Disadvantage
Memory fragmentation. Eg. many memory allocators have page alignment constraints for convenience, which could waste up to the remaining 60K if the memory actually in use fits entirely within a 4K page instead.